Shuichi Sato, Ph.D., ATC

Assistant professor, Lab Coordinator, Exercise Science/Kinesiology
Researcher in New Iberia Research Center (NIRC)
University of Louisiana at Lafayette

Office: Bourgeois Hall 134A, Email: s.sato@louisiana.edu

My research interest lies on the alternation of skeletal muscle size, physiology, and function due to external stimuli such as aging, cancer and disuse and effects of exercise training in addition to pharmacological/nutritional reagents using in vitro and in vivo models.

My research career began in the Analytical Chemistry lab where I investigated the solvent-solute interaction between organic solvent and organometalic complex using mathematical models. Since I moved to the US, my interest shifted toward biology/physiology in humans ending up working on research at Integrative Muscle Biology lab of Dr. Carson in the Univ. of South Carolina. After getting a terminal degree at the institution, I had further research training at Dr. Kumar lab in the University of Louisville, School of Medicine.

I played football (not soccer) in high school and college in my country. So football is still my favorite sport and I like to watch football games in my spare time. But recently aging process teaches me how important physical activity/exercise is, mandating me to step on treadmill regularly. This experience further motivates me to study the role of exercise to fight against common chronic diseases.

Education & Training

2015 - Post-Doc, Cell Biology, Univ. of Louisville School of Medicine

2012 - Ph.D., Applied Physiology, Univ. of South Carolina

2005 - MS, Exercise Science, Univ. of Southern Mississippi

2003 - BS, Athletic Training, Univ. of Southern Mississippi

1996 - MS, Chemistry, Sophia University

1994 - BS, Chemistry, Sophia University



Yamada Research Fund (PI: Sato, 2016-2017)
Title: The effect of royal jelly on satellite cell activation in aged nonhuman primate in vitro

Louisiana BoRSF Research Competitiveness Subprogram (PI: Sato, 2017-2020)
Title:The effect of Yes-associated protein YAP during the development of cancer cachexia

Research Interests

  • Skeletal muscle
  • Satellite Cells
  • Hippo signaling
  • CRISPR-Cas9
  • Proteomics/Metabolomics
While molecular/cell biology techniques has been used for my studies, I would like to integrate analytical chemistry approach into my future research agenda. So I am willing to welcome students/scholars who have different experiences/backgrounds to my lab.

Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia

Bohnert KR, Gallot YS, Sato S, Xiong G, Hindi SM, and Kumar A.

FASEB J. 2016 Sep;30(9):3053-68. doi: 10.1096/fj.201600250RR.

Keywords: Cancer cachexia, ER stress, skeletal muscle, AKT, Unfolding protein response

Eccentric Contraction-Induced Myofiber Growth in Tumor-Bearing Mice

Hardee JP, Mangum J, Gao S, Sato S, Hetzler KL, Puppa MH, Fix D, and Carson JA.

J Appl Physiol (1985). 2016 Jan 1;120(1):29-37. doi: 10.1152/japplphysiol.00416.2015.

Keywords: cancer cachexia, eccentric contractions, high-frequency electrical stimulation, muscle inflammation, myofiber growth

TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair

Ogura Y, Hindi SM, Sato S, Xiong G, Akira S, and Kumar A.

Nat Commun. 2015 Dec 9;6:10123. doi: 10.1038/ncomms10123

Keywords: transforming growth factor-b-activated kinase 1, TAK1, muscle regeneration, satellite cell

Sex differences in the relationship of IL-6 signalling to cancer cachexia progression

Hetzler KL, Hardee JP, Puppa MJ, Narsale AA, Sato S, Davis JM, and Carson JA.

Biochim Biophys Acta. 2015 May;1852(5):816-25. doi: 10.1016/j.bbadis.2014.12.015.

Keywords: Apc(Min/+), IL-6r, SOCS3, STAT3, Skeletal muscle.

Elevated levels of TWEAK in skeletal muscle promote visceral obesity, insulin resistance, and metabolic dysfunction

Sato S, Ogura Y, Tajrishi MM, and Kumar A.

FASEB J. 2015 Mar;29(3):988-1002. doi: 10.1096/fj.14-260703.

Keywords: AMPK, Fn14, GLUT4, PGC-1α, type 2 diabetes

Therapeutic potential of matrix metalloproteinases in Duchenne muscular dystrophy

Ogura Y, Tajrishi MM, Sato S, Hindi SM, Kumar A.

Front Cell Dev Biol. 2014 Apr 1;2:11. doi: 10.3389/fcell.2014.00011. eCollection 2014.

Keywords: NF-κB, TIMPs, fibrosis, inflammation, macrophages, matrix metalloproteinases, skeletal muscle

The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle

Tajrishi MM, Sato S (equal contribution), Shin J, Zheng TS, Burkly LC, Kumar A.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1219-24. doi: 10.1016/j.bbrc.2014.03.084.

Keywords: Autophagy, Cytokines, NF-κB, Sarcopenia, Ubiquitin–proteasome system

TWEAK/Fn14 Signaling Axis Mediates Skeletal Muscle Atrophy and Metabolic Dysfunction

Sato S, Ogura Y, and Kumar A.

Front Immunol. 2014 Jan 27;5:18. doi: 10.3389/fimmu.2014.00018. eCollection 2014.

Keywords: Fn14, TWEAK, atrophy, oxidative phosphorylation, skeletal muscle

Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy

Hindi SM, Sato S, Choi Y, and Kumar A

Hum Mol Genet. 2014 Mar 15;23(6):1492-505. doi: 10.1093/hmg/ddt536.

Keywords: TRAF6, Duchenne muscular dystrophy, nf-kb

TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity

Sato S, Ogura Y, Mishra V, Shin J, Bhatnagar S, Hill BG, and Kumar A

Skelet Muscle. 2013 Jul 8;3(1):18. doi: 10.1186/2044-5040-3-18.

Keywords: Skeletal muscle, exercise tolerance, TWEAK, Fn14, PGC-1α, PPARδ

Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK

White JP, Puppa MJ, Gao S, Sato S, Welle SL, and Carson JA

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1042-52. doi: 10.1152/ajpendo.00410.2012

Keywords: AMPK, IGF-I, IL-6, STAT, cachexia, colorectal cancer, exercise, inflammation, mTOR, muscle, protein synthesis, wasting

Development of an UPLC mass spectrometry method for measurement of myofibrillar protein synthesis: application to analysis of murine muscles during cancer cachexia.

Lima M, Sato S, Enos RT, Baynes JW, and Carson JA

J Appl Physiol (1985). 2013 Mar 15;114(6):824-8. doi: 10.1152/japplphysiol.01141.2012.

Keywords: cachexia, myofibrillar protein synthesis, soleus, plantaris, ultra-performance liquid chromatography mass spectrometry

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle

White JP, Gao S, Puppa MJ, Sato S, Welle SL, and Carson JA.

Mol Cell Endocrinol. 2013 Jan 30;365(2):174-86. doi: 10.1016/j.mce.2012.10.019.

Keywords: Muscle, Testosterone, FOXO3a, Akt, mTOR, AMPK

IL-6 regulation of muscle mitochondrial biogenesis and fission/fusion dynamics during the progression of cancer cachexia

White JP, Sato S, Puppa MJ, Baynes JW, Kostek, MC, Matesic LE and Carson JA.

Skeletal Muscle. 2012 Jul 6;2:14. doi: 10.1186/2044-5040-2-14.

Keywords: FIS1, PGC-1α, Exercise, IL-6r, MFN1, Cachexia, Mitochondria, Muscle, Autophagy

The Effect of Exercise on IL-6-induced Cachexia in the ApcMin/+ mouse

Puppa MJ, White JP, Velasquez KT, Baltgalvis KA, Sato S, Baynes JW, and Carson JA.

J Cachexia Sarcopenia Muscle. 2012 Jun;3(2):117-37. doi: 10.1007/s13539-011-0047-1.

Keywords: Inflammation, Colorectal cancer, Insulin resistance, Oxidative capacity

Gut barrier dysfunction in the ApcMin/+ mouse model of colon cancer cachexia

Puppa MJ, White JP, Sato S, Cairns M, Baynes JW, and Carson JA.

Biochimica et Biophysica Acta – Molecular Basis of Disease. Dec;1812(12):1601-6.

Keywords: Cachexia, Colorectal cancer, Endotoxin, Gut barrier dysfunction, Gut permeability, Inflammation

The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the ApcMin/+ mouse

White JP, Baynes JW, Welle SL, Kostek MC, Matesic LE, Sato S, and Carson JA.

PLoS ONE 6(9): e24650. doi:10.1371/journal.pone.0024650

Keywords: cachexia, protein synthesis, protein degradation, mTOR, FOXO, Ubiquitin–proteasome system

Skeletal muscle mass recovery from atrophy in IL-6 knockout mice

Washington TA, White JP, Davis JM, Wilson LB, Lowe LL, Sato S, and Carson JA.

Acta Physiol (Oxf). Acta Physiol (Oxf). 2011 Aug;202(4):657-69.

Keywords: inflammation, myogenesis, muscle regeneration, hypertrophy, IGF-1, mTOR, Stat3

Muscle oxidative capacity during IL-6 dependent cancer cachexia

White JP, Baltgalvis KA, Puppa MJ, Sato S, Baynes JW, and Carson JA.

Am J Physiol Regul Integr Comp Physiol; 2011 Feb;300(2):R201-11.

Keywords: mitochondria, wasting, mitofusin-2 protein, fission 1 protein

The effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury

White JP, Baltgalvis KA, Sato S, Wilson LB, and Carson JA

J Appl Physiol. 2009 Nov;107(5):1420-30.

Keywords: muscle regeneration, anabolic steroids, myotoxin

Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6.

White JP, Reecy JM, Washington TA, Sato S, Le ME, Davis JM, Wilson LB, and Carson JA

Acta Physiol (Oxf). 2009 Dec;197(4):321-32.



A research graduate assistantship available in Fall 2018 (Master's student in Kinesiology)

This position (2 years) is for a current undergraduate student who is interested in skeletal muscle biology research and hopefully pursuing research career in the future. Biology/Chemistry background and research experience will be a plus, but not required. Instead, a good work ethic will be mandatory. Please email Dr. Sato for details if interested. Application due: March 31, 2018.



A new manuscript has been published in JCI insight on 2/8/2018. https://insight.jci.org/articles/view/98441


Sato received Travel Grants for Emerging Faculty (TGEF) from Louisiana Experimental Program to Stimulate Competitive Research (EPSCoR) in September 2017.

Research Presentation

Undergraduate students Janesha and Ben in Sato's lab presented their poster at Experimental Biology 2017 in Chicago. Title of the presentation was: The Role of Hippo Signaling Pathway on Muscle Wasting in ApcMin/+ Mice: A Pilot Study.


Our lab's proposal to BoRSF Research Competitiveness Subprogram (RCS) was recommended for funding in April 2017.

Get in Touch!

Last update: November 6, 2017